Metal-free alpha trifluoromethylselenolation of carbonyl derivatives under batch and flow conditions

Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF 3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF 3 species. We also implemented an in-flow protocol to improve the safety features of the process.