The First Skeletal Rearrangement of Aspidosperma to Melodinus Alkaloids. A Facile Conversion of (-)-Vincadifformine into N-Methy Ltetrahy Dromeloscinet

A facile approach to N-methyltetrahydromeloscine 18 starting from the readily available (-)-vincadifformine 11 was developed in a model study directed toward the synthesis of meloscine-type Melodinus alkaloids. © 1984, American Chemical Society. All rights reserved.