Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
Articolo
Data di Pubblicazione:
2018
Abstract:
Background For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. Methods The STAR Network “Depot” Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. Results Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. Discussion LAIs' prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.
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Articolo su Rivista
Elenco autori:
Ostuzzi, Giovann; Mazzi, Maria Angela; Terlizzi, Samira; Bertolini, Federico; Aguglia, Andrea; Bartoli, Francesco; Bortolaso, Paola; Callegari, Camilla; Caroleo, Mariarita; Carrà, Giuseppe; Corbo, Mariangela; D'Agostino, Armando; Gastaldon, Chiara; Lucii, Claudio; Magliocco, Fabio; Martinotti, Giovanni; Nosé, Michela; Ostinelli, Edoardo Giuseppe; Papola, Davide; Piccinelli, Marco Piero; Piccoli, Alberto; Purgato, Marianna; Tabacchi, Tommaso; Turrini, Giulia; Ruggeri, Mirella; Barbui, Corrado; De Fazio, Pasquale; Raffaele, Gaetano; Chirico, Margherita; Cavallotti, Simone; Bolognesi, Simone; Debolini, Sara; Pierantozzi, Elisa; Fargnoli, Francesco; Del Zanna, Maria; Giannini, Alessandra; Luccarelli, Livia; De Capua, Alberto; Annese, Pasqua Maria; Cerretini, Massimiliano; Tozzi, Fior-Ella; Magnani, Nadia; Cardamone, Giuseppe; Bardicchia, Francesco; Facchi, Edvige; Soscia, Federica; Zotos, Spyridon; Biancosino, Bruno; Zonta, Filippo; Pompei, Francesco; Zizolfi, Daniele; Poloni, Nicola; Ielmini, Marta; Caselli, Ivano; Giana, Edoardo; Buzzi, Aldo; Diurni, Marcello; Milano, Anna; Sani, Emanuele; Calzolari, Roberta; Piccinelli, Marco; Cazzamalli, Sara; Alberini, Gabrio; Piantanida, Silvia; Costantini, Chiara; Paronelli, Chiara; Di Caro, Angela; Moretti, Valentina; Gozzi, Mauro; D'Ippolito, Chiara; Barbanti, Silva Veronica; Alessandro, Papalini; Campese, Ornella; Fiori, Federica; Lorusso, Marco; Di Capro, Lucia; Viceconte, Daniela; Mancini, Valerio; Suraniti, Francesco; Signorelli, Maria Salvina; Rossi, Eugenio; Lupoli, Pasqualino; Menchetti, Marco; Terzi, Laura; Boso, Marianna; Risaro, Paolo; De Paoli, Giuseppe; Catania, Cristina; Tarricone, Ilaria; Caretto, Valentina; Storbini, Viviana; Emiliani, Roberta; Balzarro, Beatrice; Nava, Roberto; Bono, Adele; Provenzi, Milena; Brambilla, Giulia; Aspesi, Flora; Tremolada, Martina; Castagna, Gloria; Bava, Mattia; Verrengia, Enrica; Lucchi, Sara; Oriani, Maria Ginevra; Barchiesi, Michela; Pacetti, Monica; Magni, Laura Rosa; Rossi, Giuseppe; Beneduce, Rossella; Tura, Giovanni Battista; Laffranchini, Laura; Mastromo, Daniele; Ferrato, Farida; Restaino, Francesco; Monzani, Emiliano; Porcellana, Matteo; Limosani, Ivan; Ghio, Lucio; Ferro, Maurizio; Parise, Vincenzo Fricchione; Balletta, Giovanni; Addeo, Lelio; De Vivo, Elisa; Benedetto, Rossella Di; Pinna, Federica; Carpiniello, Bernardo; Spano, Mariangela; Giacomin, Marzio; Pecile, Damiano; Mattei, Chiara; Fabrici, Elisabetta Pascolo; Panarello, Sofia; Peresson, Giulia; Vitucci, Claudio; Bonavigo, Tommaso; Perini, Giovanni; Boschello, Filippo; Strizzolo, Stefania; Gardellin, Francesco; Di Giannantonio, Massimo; Moretti, Daniele; Fizzotti, Carlo; Cossetta, Edoardo; Gregorio, Luana Di; Sozzi, Francesca; Boncompagni, Giancarlo; La Barbera, Daniele; Colli, Giuseppe; Laurenzi, Sabrina; Calandra, Carmela; Luca, Maria
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