The course aims to provide students with an advanced understanding of the molecular and genetic mechanisms underlying malignant sinonasal tumors, with particular emphasis on the integration of basic sciences and clinical disciplines. By the end of the course, students will be able to appreciate the clinical relevance of genetic and molecular profiling of neoplasms for biological classification, prognostic stratification, and therapeutic decision-making. The course also aims to develop critical skills for interpreting molecular data to guide personalized treatment strategies, identifying high-risk patients who may benefit from treatment intensification, while selecting tailored therapeutic approaches based on tumor-specific biological characteristics, in accordance with the principles of precision medicine.
Course Prerequisites
General histological and anatomical knowledge
Teaching Methods
Lectures with slides
Assessment Methods
oral examination
Contents
The course addresses the fundamental concepts of molecular oncology applied to malignant tumors of the sinonasal tract, highlighting the biological and clinical rationale for genetic and molecular profiling of neoplasms. Key topics include genomic and epigenetic alterations, tumor microenvironment characteristics, and their role in tumor progression, treatment response, and patient prognosis. Particular emphasis is placed on the translational approach, bridging basic research and clinical practice, and on the evolution of modern therapeutic strategies, including molecularly targeted therapies, immunotherapy, induction chemotherapy, and advanced radiation techniques. The concept of precision medicine, defined as treatment tailored to the individual patient and to the specific biological features of each tumor, represents the unifying framework of the course.
Course Language
Italian
More information
The course is designed as a translational course bridging basic sciences and clinical disciplines.
