Atrio-ventricular junction: Can precision electrocardiology bridge cell and electrocardiogram?

The Atrio Ventricular Junction (AVJ) is a well-defined anatomical region of the heart the physiology of which, despite extensive and numerous observations, it is not fully understood. The aim of this review is to present an up to date summary of old and more recent findings on histology, cellular electrophysiology and intracellular connectivity of this region. We have also attempted to relate our increasing understanding of nodal pathophysiology to the interpretation of the electrocardiographic (ECG) manifestations of AVN behavior. Bridging cellular observations with ECG analysis in a process we call “Precision Electrocardiology” renders this tool far more sensitive and clinically useful than the pattern analysis too often employed in the ECG interpretation.