Malignant Tumours

Sinonasal malignant tumours generally present insidiously and in advanced stages and as such are often associated with poor survival outcomes. Adequate diagnostic workup is of utmost importance for planning the most appropriate treatment strategy, which is driven by the tumour histotype, and the management requires the cooperation in a multidisciplinary oncologic skull base team. A wide spectrum of malignancies with different biological aggressiveness can affect the sinonasal tract, with adenocarcinoma and squamous cell carcinoma being the most common. Integration of multimodal treatment strategies, with different regimens of chemotherapy and radiotherapy, is able to improve survival outcomes.