Orgasm and Ejaculation Disorders

Disorders of ejaculations are among the most complex complaints of patients seeking first medical help for sexual dysfunction. Among these, premature ejaculation (PE), delayed ejaculation (DE), retrograde ejaculation, and anorgasmia are the most frequently reported, and their impact on patients’ quality of life can be major. Although numerous preclinical and clinical studies have been published over the last two decades, the true pathophysiological mechanisms behind ejaculation remain unclear. In this context, this chapter aims at providing the latest evidence regarding ejaculation physiology together with detailed epidemiological data, diagnostic work-up, and treatment options upon PE, DE, retrograde ejaculation, and anorgasmia.