The laboratory carries out phenotypic and functional characterization of immune cells, in particular Natural Killer cells and macrophages, from clinical samples of peripheral blood and tumor tissues from patients with various types of neoplasms, such as prostate cancer, cancer of the non-small cell lung, multiple myeloma, and ovarian cancer. Various molecules and chemical compounds are also studied, many of which of natural origin, such as metformin, xanthumol and acetyl-L-carnitine, for their anti-angiogenic activity in prostate cancer in mice.
The teaching staff studies the involvement of several innate immune cells in the angiogenic process of tumors, the oncosuppressive function of the RNASET2 ribonuclease in in vitro and in vivo systems in the murine syngeneic model, in collaboration with the Laboratory of Genetics, DBSV. Furthermore, another subject of investigation is the role of Natural Killer cells in autoimmune hyperthyroid patients with Graves' disease, undergoing drug therapy with Tapazole and before and after treatment with vitamin D and Selenium, and the in vitro role of Cetuximab-dependent antibody cytolysis of Natural Killer cells in subjects with hypovitaminosis and after treatment with vitamin D supplement towards colon cancer line.
Address:
Via Monte Generoso, 71C, 21100 Varese VA, Italia
date/time interval:
(January 1, 2020 - )