Person
CARRO MARIA STELLA
Ricercatori a tempo determinato
Course Catalogue:
Communications
Overview
During my scientific career, I have developed strong expertise in cancer research, initially as a postdoctoral researcher at the IEO-IFOM Campus in Milan and later at the Institute for Cancer Genetics, Columbia University, where I focused on brain tumor research. My work aims to identify deregulated signaling, transcriptional, genetic, and epigenetic mechanisms driving glioblastoma (GBM) aggressiveness and affecting patient survival.
A major achievement of my postdoctoral work was the identification of master regulators of the mesenchymal signature in glioma. In a Nature publication (2010), I demonstrated the critical role of STAT3 and C/EBPβ in gliomagenesis, providing the first comprehensive mapping of transcription factors controlling the mesenchymal GBM phenotype.
After establishing my independent research in Germany with support from Marie Curie and DFG grants, I extended my studies through systems biology and epigenetic approaches, identifying ANXA2 as an epigenetically regulated gene linked to mesenchymal gene expression and patient survival.
As group leader at the University of Freiburg, I characterized ZBTB18 as a tumor suppressor in GBM, showing that its loss promotes invasive mesenchymal traits, lipid biosynthesis, and tumor-promoting microglia recruitment. This work, previously supported by the German Cancer Aid, is now expanded at the University of Insubria.
Attachment (CV)
CV_CARRO.docx (Carro CV)
Description
EDUCATION
2023–present – Abilitation in General and Clinical Pathology (06/A2), Italy
2019 – Abilitation, Experimental Medicine, University of Freiburg
2002 – PhD in Developmental Biology, University of Milan
1998 – MSc in Biology, University of Insubria
ACADEMIC APPOINTMENTS
1 Sept 2024 – Present
Assistant Professor (RTDb), Laboratory of General Pathology and Immunology, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy
1 Oct 2012 – 31 Aug 2024
Group Leader, Neuro-oncology Unit, Department of Neurosurgery, University Medical Center Freiburg, Germany
1 Oct 2009 – 30 Sept 2012
Team Leader, Neuro-oncology Laboratory, Department of Neurosurgery, University Medical Center Freiburg, Germany
1 Sept 2005 – 30 Sept 2009
Postdoctoral Research Scientist, ICG, Columbia University, New York, USA
1 June 2002 – 31 Aug 2005
Postdoctoral Researcher, IEO (European Institute of Oncology), Milan, Italy
1 Nov 1998 – 30 June 2002
PhD Candidate, Department of Functional and Structural Biology, University of Insubria, Varese, Italy
SELECTED PUBLICATIONS
1) Ferrarese, R. et al. and Carro M.S. ZBTB18 regulates cytokine expression and affects microglia/macrophage recruitment and commitment in glioblastoma. https://doi.org/10.1038/s42003-024-07144-y
2) R. Ferrarese et al. and M.S. Carro. ZBTB18 inhibits SREBP-dependent lipid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma. doi: 10.26508/lsa.202201400.
3) A. P Masilamani et al. and M. S. Carro. Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism. doi:10.1016/j.isci.2022.104625.
4) Fedele V. et al. and Carro MS. Epigenetic regulation of ZBTB18 promotes glioblastoma progression. doi: 10.1158/1541-7786.MCR-16-0494.
5) Ferrarese R. et al. and Carro MS*, Bredel M*.Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. doi: 10.1172/JCI68836.
2023–present – Abilitation in General and Clinical Pathology (06/A2), Italy
2019 – Abilitation, Experimental Medicine, University of Freiburg
2002 – PhD in Developmental Biology, University of Milan
1998 – MSc in Biology, University of Insubria
ACADEMIC APPOINTMENTS
1 Sept 2024 – Present
Assistant Professor (RTDb), Laboratory of General Pathology and Immunology, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy
1 Oct 2012 – 31 Aug 2024
Group Leader, Neuro-oncology Unit, Department of Neurosurgery, University Medical Center Freiburg, Germany
1 Oct 2009 – 30 Sept 2012
Team Leader, Neuro-oncology Laboratory, Department of Neurosurgery, University Medical Center Freiburg, Germany
1 Sept 2005 – 30 Sept 2009
Postdoctoral Research Scientist, ICG, Columbia University, New York, USA
1 June 2002 – 31 Aug 2005
Postdoctoral Researcher, IEO (European Institute of Oncology), Milan, Italy
1 Nov 1998 – 30 June 2002
PhD Candidate, Department of Functional and Structural Biology, University of Insubria, Varese, Italy
SELECTED PUBLICATIONS
1) Ferrarese, R. et al. and Carro M.S. ZBTB18 regulates cytokine expression and affects microglia/macrophage recruitment and commitment in glioblastoma. https://doi.org/10.1038/s42003-024-07144-y
2) R. Ferrarese et al. and M.S. Carro. ZBTB18 inhibits SREBP-dependent lipid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma. doi: 10.26508/lsa.202201400.
3) A. P Masilamani et al. and M. S. Carro. Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism. doi:10.1016/j.isci.2022.104625.
4) Fedele V. et al. and Carro MS. Epigenetic regulation of ZBTB18 promotes glioblastoma progression. doi: 10.1158/1541-7786.MCR-16-0494.
5) Ferrarese R. et al. and Carro MS*, Bredel M*.Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. doi: 10.1172/JCI68836.
Overview
My scientific activity focuses on characterizing the molecular mechanisms associated with the progression of glioblastoma (GBM), the most aggressive and deadly brain tumor in adults. This tumor is characterized by high plasticity and heterogeneity, with cells in different states reminiscent of different developmental stages. MES-like cells contain a high percentage of slow-cycling cells, termed quiescent GBM (qGBM), which are important for therapy resistance and for evading immune surveillance, contributing to the immunosuppressive environment of GBM. We have previously identified ZBTB18 as a transcriptional repressor of MES genes and a tumor suppressor in GBM. The group is currently involved in several projects aimed at better understanding the role of ZBTB18 and associated factors in maintaining quiescence and regulating tumor antigen expression.
No Results Found
Member of
Molecular Neuro-oncology
GroupOther research activities
Dissecting the contribution of ZBTB18 and TIP60 complex to the mesenchymal/quiescent state in GBM
Progetti interamente finanziati dall'Ateneo
Project
Scientific Manager
2026
12 months
No Results Found
Publications (29)
Research and teaching at institutions (3)
Position carried out at: Università degli Studi INSUBRIA Varese-Como - Ricercatore/Ricercatrice universitario a t.d.
(01/09/2024 - 31/08/2027)20240901
Group leader at: Albert-Ludwigs-Universität Freiburg - Ricercatore/Ricercatrice all’estero
(01/10/2012 - )20121001
Senior post-doc/team leader at: Albert-Ludwigs-Universität Freiburg - Ricercatore/Ricercatrice all’estero
(01/10/2009 - 30/09/2012)20091001
No Results Found
Tutoring
tutorship -
Altro
- ZANZI LUCREZIA
No Results Found
Courses (11)
6 CFU
75 hours
8 CFU
76 hours
1 CFU
12 hours
5 CFU
66 hours
5 CFU
66 hours
3 CFU
36 hours
3 CFU
36 hours
2 CFU
30 hours
1 CFU
15 hours
5 CFU
75 hours
6 CFU
75 hours
No Results Found
Third Mission (2)
Attività di coinvolgimento e interazione con il mondo della scuola (Responsabile scientifico)
- Partecipazione alla notte dei ricercatori con il laboratorio AIRC "Diversi da chi"
Ateneo e villa Mirabella (26/09/2025 - 27/09/2025) 20250926
DIPARTIMENTO DI MEDICINA E INNOVAZIONE TECNOLOGICA
Attività di coinvolgimento e interazione con il mondo della scuola (Responsabile scientifico)
- Partecipazione alla notte dei ricercatori con il laboratorio AIRC "mangiamo veramente?"
Ateneo e Piazza Montegrappa (Varese) (27/09/2024 - ) 20240927
DIPARTIMENTO DI MEDICINA E INNOVAZIONE TECNOLOGICA
No Results Found