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Research Center in Genomic Medicine

Group
The Center for Genomic Medicine aims to promote integration among the activities of researchers and faculty members from different scientific and disciplinary fields, fostering an interdisciplinary approach focused on innovation and knowledge transfer. The Center serves as a bridge between clinical medicine and basic sciences, recognizing that the application of genomics to clinical practice requires increasingly integrated expertise. In this context, particular importance is attached to collaboration with bioinformatics and to the use of artificial intelligence in the interpretation of genomic data, as well as to interaction with psychology and the development of the soft skills required for effective physician-patient communication, particularly when dealing with complex diagnoses, advanced molecular testing, and clinical pathways requiring appropriate informed consent. Within this new vision of medicine, the medical geneticist is progressively assuming the role of a “disease manager,” coordinating the diagnostic process and acting as a liaison among the various specialists involved in multidisciplinary boards, with the aim of integrating genomic, clinical, and individual information into patient management.
Address:
Via J.H. Dunant, 5 - 21100 - Varese (VA)
date/time interval:
(June 21, 2019 - )
  • Overview
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Overview

Acronym

CMG

Term type

Gruppo di ricerca strategica

Linked Units

DIPARTIMENTO DI MEDICINA E CHIRURGIA

Research Fields

Concepts (4)


LS2_1 - Genomics, comparative genomics, functional genomics - (2016)

Goal 3: Good health and well-being

Settore MED/03 - Genetica Medica

Settore MEDS-01/A - Genetica medica

Keywords (3)

Genomica
Sindromi ereditarie
medicina di precisione oncologica
No Results Found

Overview

Analysis of the role of the genome in the pathogenesis of human diseases, with particular focus on its interaction with the environment, and Precision Medicine studies based on the recent development of advanced molecular technologies capable of implementing and integrating “4P Medicine” approaches into clinical practice: Predictive, Preventive, Personalized, and Participatory Medicine. Application of artificial intelligence models to the recognition and classification of normal and pathological karyotypes. Studies on the integration of augmented reality into medical education, particularly in teaching doctor–patient communication during critical genetic counseling sessions, where the development of students’ soft skills may contribute to improving their future clinical practice. Genetic studies of retinal diseases. The African population is of particular importance in human genetics, as it exhibits the highest genetic diversity worldwide, reflecting the deepest roots of the human evolutionary tree. From a medical perspective, African genomes have historically been underrepresented in genetic databases, resulting in significant gaps in the identification and characterization of clinically relevant genetic variants. We are therefore beginning to offer, also within the framework of existing healthcare collaborations, genetic testing to Malagasy patients affected by retinopathies and maculopathies. Our expertise in digital medicine, telemedicine, and artificial intelligence, together with planned collaborations with researchers and clinicians specializing in maculopathies, will provide valuable support for these activities. Study of gene expression in the MIO-M1 cell line following micropulse laser treatment. Several ischemia-related degenerative retinal diseases benefit from treatment with subthreshold micropulse laser irradiation, although the underlying mechanisms are not yet fully understood. The experimental study conducted by Dr. Premi during his PhD in Life Sciences and Biotechnology, which culminated in the thesis entitled “Innovative diagnostic and therapy pathway for patients with maculopathy, from genetics and biomarkers to telemedicine,” investigated the effects of subthreshold micropulse laser treatment on the MIO-M1 (Müller glial) cell line. Transcriptomic analysis identified the modulation of specific genes involved in inflammation and angiogenesis.
No Results Found

Affiliation

Collaboration with other Workgroups (5)

Center for Clinical Ethics
Center of Research in Medical Pharmacology
Human Genetics Laboratory- DBSV - VARESE, ITALY
Molecular Genetics
Genetica di Popolazioni

Has member

PORTA GIOVANNI

List of all contributors

Antoniotti Marco, Casalone Rosario, Frattini Annalisa, Palomba Lia, Schlessinger David

Members (15)

ACQUATI FRANCESCO
BINELLI GIORGIO PIETRO MARIO
COSENTINO MARCO
DALLA GASPERINA DANIELA
DONATI SIMONE
FERRARI MARCO
FERRARIO MARCO MARIO ANGELO
GIANFAGNA FRANCESCO
GUASTI LUIGINA
MONTALBANO GIUSEPPE
PASSI ALBERTO GIUSEPPE
PORTA GIOVANNI
TOZZI MATTEO
VALDATTA LUIGI
VALLI ROBERTO

Outputs

Publications (167)

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Contact

Phone

0332 397101

Web site

http://www.uninsubria.it/node/11032

Equipments & Resources

Laboratories (2)

HUMAN AND MOLECULAR GENETICS LABORATORIES - DBSV
MEDICAL GENETICS LABORATORY - DMC - VARESE

Equipments (2)

Laser microarray scanner
SEQUENZIATORE REGOLAMENTATO FDA E MARCATO CE IN VITRO DIAGNOSTICO
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