ID:
SCV0499
Durata (ore):
48
CFU:
6
SSD:
BIOLOGIA APPLICATA
Anno:
2024
Dati Generali
Periodo di attività
Secondo Semestre (24/02/2025 - 20/06/2025)
Syllabus
Obiettivi Formativi
The aim of the course is to introduce the students to the biological and
molecular aspects of neoplastic transformation and to explore how these
mechanisms are altered in different types of cancer. Emphasis will be
given to the events that drive cancer initiation, cancer progression and
metastatic dissemination. The role of the micro-environment will also be
deeply investigated, now considered to be a key player in supporting all
phases of the development of cancer.
At the end of the course, the students will:
get to know the fundaments of molecular mechanism of cancer onset,
progression and metastasis
describe the reciprocal relationship between the microenvironment and
tumour cells
distinguish the role of cancer stem cells from the bulk tumour cells
return the complexity of the epigenetic processes involved in tumour
progression
build conceptual maps for the explanation of the still unresolved aspects
of genetic and epigenetic hierarchy during tumour onset and progression
search PubMed for the relevant scientific articles for their exam
This course will also provide the students with the opportunity to develop
as adult learners and as effective contributors in a professional
environment by:
1. Being responsible for their own learning and for the depth of their own
study.
2. Using their own initiative to make use of all the available resources to
complement lecture material, including academic staff resources.
3. Working in a team environment and contributing effectively to their
own learning and to that of their peers by questioning each other and
academic staff when uncertain.
4. Developing communication skills by effective interaction with peers
and academic staff.
The optional Cellular and Molecular Oncology course is part of the two
curricula (Basic and Applied Biomedical Sciences and Double Degree) of
the first year of the Master's Degree in Biomedical sciences, allowing the
student to study in depth cellular and molecular bases that govern
pathological processes in oncology
molecular aspects of neoplastic transformation and to explore how these
mechanisms are altered in different types of cancer. Emphasis will be
given to the events that drive cancer initiation, cancer progression and
metastatic dissemination. The role of the micro-environment will also be
deeply investigated, now considered to be a key player in supporting all
phases of the development of cancer.
At the end of the course, the students will:
get to know the fundaments of molecular mechanism of cancer onset,
progression and metastasis
describe the reciprocal relationship between the microenvironment and
tumour cells
distinguish the role of cancer stem cells from the bulk tumour cells
return the complexity of the epigenetic processes involved in tumour
progression
build conceptual maps for the explanation of the still unresolved aspects
of genetic and epigenetic hierarchy during tumour onset and progression
search PubMed for the relevant scientific articles for their exam
This course will also provide the students with the opportunity to develop
as adult learners and as effective contributors in a professional
environment by:
1. Being responsible for their own learning and for the depth of their own
study.
2. Using their own initiative to make use of all the available resources to
complement lecture material, including academic staff resources.
3. Working in a team environment and contributing effectively to their
own learning and to that of their peers by questioning each other and
academic staff when uncertain.
4. Developing communication skills by effective interaction with peers
and academic staff.
The optional Cellular and Molecular Oncology course is part of the two
curricula (Basic and Applied Biomedical Sciences and Double Degree) of
the first year of the Master's Degree in Biomedical sciences, allowing the
student to study in depth cellular and molecular bases that govern
pathological processes in oncology
Prerequisiti
In order to follow the course, an adequate knowledge of cell and molecular biology, biochemistry and physiology is required.
Metodi didattici
The course topics will be dealt with lectures-style instruction with the use of electronic presentations.
Each lesson will be subdivided in three rounds of 50min each, two breaks of 10min and 15 minutes of discussion with the students on the topics covered, for a total of three hours.
Working groups will be organized on specific issues related to the course topics.
Each lesson will be subdivided in three rounds of 50min each, two breaks of 10min and 15 minutes of discussion with the students on the topics covered, for a total of three hours.
Working groups will be organized on specific issues related to the course topics.
Verifica Apprendimento
Oral exams. For the exam, the student will prepare a presentation on one of the topics discussed during the course. The students will be provided with a list of specific topics, among which they will chose one for the preparation of a presentation. Updated reviews and research articles for the presentation will be provided on each topic. The students will need to further search on PubMed for additional research articles on the topic of interest to personalise their presentation.
The presentation will be prepared on the basis of the material provided and of the further articles the students will have retrieved from PubMed and must not be longer than 40 min, 15 min of discussion will follow.
The students need to demonstrate:
sufficient knowledge of the specific topic presented
the ability to discuss cutting edge cellular and molecular aspect of oncology
the correct use of scientific terms
to be able to make connections between the topics covered during the course and those not included in the presentation
The presentation will be prepared on the basis of the material provided and of the further articles the students will have retrieved from PubMed and must not be longer than 40 min, 15 min of discussion will follow.
The students need to demonstrate:
sufficient knowledge of the specific topic presented
the ability to discuss cutting edge cellular and molecular aspect of oncology
the correct use of scientific terms
to be able to make connections between the topics covered during the course and those not included in the presentation
Contenuti
1) The tumour burden.
2) Genetic alterations in cancer cells.
3) The Nature of Cancer.
4) Tumour viruses.
5) Cellular oncogenes and tumour suppressors.
6) Growth factors and their receptors.
7) Control of the Cell Cycle Clock.
8) Cell Immortalization and Tumorigenesis.
9) Cancer Stem cells, a hierarchy-based model for tumour generation and progression.
10) Maintenance of genomic integrity and the development of cancer.
11) Angiogenesis and cancer.
12) The role of the micro-environment in cancer development.
13) Multistep tumorigenesis.
14) Invasion and Metastasis.
2) Genetic alterations in cancer cells.
3) The Nature of Cancer.
4) Tumour viruses.
5) Cellular oncogenes and tumour suppressors.
6) Growth factors and their receptors.
7) Control of the Cell Cycle Clock.
8) Cell Immortalization and Tumorigenesis.
9) Cancer Stem cells, a hierarchy-based model for tumour generation and progression.
10) Maintenance of genomic integrity and the development of cancer.
11) Angiogenesis and cancer.
12) The role of the micro-environment in cancer development.
13) Multistep tumorigenesis.
14) Invasion and Metastasis.
Lingua Insegnamento
INGLESE
Altre informazioni
The teacher receives the students after each lesson and by appointment.
https://www.uninsubria.it/hpp/ian-marc.bonapace
ian.bonapace@uninsubria.it
https://www.uninsubria.it/hpp/ian-marc.bonapace
ian.bonapace@uninsubria.it
Corsi
Corsi
BIOMEDICAL SCIENCES
Laurea Magistrale
2 anni
No Results Found
Persone
Persone
No Results Found