The case of the “serfdom” condition of phagocytic immune cells

In a modern immunological perspective, it may be asserted that the phagocytic cell should not be
considered as the "serfdom", but rather the pivot of the immune system. Indeed, the invertebrate
immunocyte as well as the vertebrate macrophage play a central role in immunity, inflammation and
stress response. The evolutionary conserved immune-neuroendocrine effector system have remained
of fundamental importance in defense against pathogens, and its efficiency increased through synergy
with the new, clonotipical recognition repertoire in vertebrates.