Trisomy 8 in Philadelphia Chromosome (Ph1)- Negative Cells in the Course of Ph1-Positive Chronic Myelocytic Leukemia

A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph1), cells with trisomy 8 and a Ph1, and cells with trisomy 8 as the sole anomaly.