Data di Pubblicazione:
2022
Abstract:
Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.
Tipologia CRIS:
Articolo su Rivista
Keywords:
Complications; Laparoscopy; Morbidity; Radical hysterectomy
Elenco autori:
Bogani, G.; Donato, V. D.; Scambia, G.; Landoni, F.; Ghezzi, F.; Muzii, L.; Panici, P. B.; Raspagliesi, F.; Casarin, J.; Di Martino, G.; Grassi, T.; Perrone, A. M.; De Iaco, P.; Multinu, F.; Berretta, R.; Capozzi, V. A.; Zupi, E.; Centini, G.; Pellegrino, A.; Corso, S.; Stevenazzi, G.; Boschi, A. C.; Comerci, G.; Greco, P.; Scutiero, G.; Sopracordevole, F.; Giorda, G.; Fichera, M.; Simoncini, T.; Caretto, M.; Sartori, E.; Ferrari, F.; Cianci, A.; Sarpietro, G.; Matarazzo, M. G.; Giampaolino, P.; Bifulco, G.; Morelli, M.; Dio, M. D.; Ferrero, A.; Biglia, N.; Barra, F.; Ferrero, S.; Cianci, S.; Chiantera, V.; Sozzi, G.; Ercoli, A.; Schettini, S.; Orlando, T.; Cannone, F. G.; Ettore, G.; Puppo, A.; Olearo, E.; Leone Roberti Maggiore, U.; Artuso, V.; Palaia, I.; Perniola, G.; Tripodi, R.; D'Auge, T. G.; Cuccu, I.; Fischetti, M.; Santangelo, G.; Casorelli, A.; Giannini, A.; D'Oria, O.; Vizzielli, G.; Restaino, S.; Bergamini, A.; Bocciolone, L.; Plotti, F.; Angioli, R.; Mantovani, G.; Ceccaroni, M.; Cassini, C.; Dominoni, M.; Giambanco, L.; Amodeo, S.; Leo, L.; Thommaset, R.; Raimondo, D.; Seracchioli, R.; Malzoni, M.; Falcone, F.; Gorlero, F.; Di Luca, M.; Busato, E.; Kilzie, S.; Dell'Acqua, A.; Scarfone, G.; Vercellini, P.; Petrillo, M.; Capobianco, G.; Ciavattini, A.; Mereu, L.; Scollo, P.; Sorbi, F.; Fambrini, M.; Romano, F.; Ricci, G.; Trojano, G.; Damiani, G. R.; Consonni, R.; Di Lorenzo, N.; Lippolis, A.; Tinelli, R.; Aguzzoli, L.; Mandato, V. D.; Palomba, S.; Tripodi, M.; Calandra, D.; Pellegrini, F.; Zullo, F.; Surico, D.; Remorgida, V.; Ruscitto, F.; Beretta, P.; Vizza, E.
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