Multicentre prospective collection of newly diagnosed glioblastoma patients:update on the Lombardia experience.

A prospective collection of newly diagnosed cases of grade IV glioma in
Lombardia, Italy, was started in 2003. In the present report, data are shown on
349 adult patients recruited up to 2005. The clinical features, pattern of care
and outcome are discussed, together with the main prognostic factors. Males were
affected more frequently than women; median age at onset was 60. Overall, gross
total tumour resection was performed in roughly 50% of the patients, and partial
resection and biopsy in 25% each; only 5 patients did not undergo histology.
Adjuvant radiotherapy was delivered to 89% and chemotherapy to 82% of patients.
Median survival was of 54 weeks. Most patients received protracted therapy with
antiepileptic drugs, despite absence of seizures; over the course of the study,
the practice pattern tended to change, shifting to the use of non-enzyme-inducing
anti-epileptic drugs.