Methanol as a C1 Source for the Synthesis of 1,3‐Polyheterocyclic Systems

A very attractive approach toward 1,3-polyheterocyclic systems was provided exploiting the copper-catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient and sustainable for the synthesis of five-, six-, and seven-membered polyheterocyclic rings.A simple, efficient and low-cost procedure for the synthesis of 1,3-polyheterocyclic systems was reported, starting from the easily accessible aminoalcohols or diaminoalkanes, using CuCl2 as catalyst, H2O2, as inexpensive oxidant agent, and methanol acting both as solvent and reagent, proceeding under mild reaction conditions.