Short-term effects of growth hormone treatment on the upper airways of non severely obese children with Prader-Willi syndrome.

The aim of this study was to establish whether short-term GH treatment causes obstructive apnea in patients with Prader-Willi syndrome and normal upper airway patency.
SUBJECTS AND METHODS: We performed an observational longitudinal 6-week GH treatment study. Thirty-four non-severely obese Prader-Willi syndrome patients (20 boys, age range 0.94-11.8 yr, media 2.24 yr) entered an observational longitudinal 6-week study. Sixteen boys received recombinant human GH (rhGH)
treatment; the remaining 18 represented the control group and received no treatment. Polysomnography monitoring and othorhinolaringoiatric video endoscopy were performed one night before and after 6 weeks of rhGH treatment (0.03 mg/kg
body weight/day). All patients underwent auxologic assessment, fasting blood glucose, insulin and IGF-I evaluation. The main polysomnographic parameter considered was total apnea hypopnea index, consisting of two components: central
apnea hypopnea index and obstructive apnea hypopnea index. All patients were free of severe or moderate upper airway obstruction when rhGH treatment began.
Our data show that short-term rhGH treatment does not cause
restrictions of the upper airways in patients with Prader-Willi syndrome and normal upper airway patency.