Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis
Articolo
Data di Pubblicazione:
2016
Abstract:
High levels of hyaluronan (HA) synthesis in various cancer tissues, including sarcomas, are correlated with tumorigenesis and malignant transformation. RHAMM (receptor for hyaluronic acid-mediated motility) is overexpressed during tumor development in different malignancies. β-Catenin is a crucial downstream mediator of the Wnt signaling cascade which facilitates carcinogenic events characterized by deregulated cell proliferation.
Tipologia CRIS:
Articolo su Rivista
Keywords:
ERK1/2; Fibrosarcoma cell proliferation; LMWHA; RHAMM; β-Catenin; Active Transport, Cell Nucleus; Antigens, CD44; Cell Line, Tumor; Cell Nucleus; Extracellular Matrix Proteins; Fibrosarcoma; Humans; Proto-Oncogene Proteins c-myc; beta Catenin; Cell Proliferation; Signal Transduction
Elenco autori:
Kouvidi, Katerina; Berdiaki, Aikaterini; Tzardi, Maria; Karousou, Evgenia; Passi, Alberto; Nikitovic, Dragana; Tzanakakis, George N.
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