BONAPACE IAN MARC

PERSONAL INFORMATION Surname and Name Bonapace Ian Marc Work address Via Manara 7, 21052 – Busto Arsizio – (Va) Telephone +39 0331 339452-05 (work) e-mail ian.bonapace@uninsubria.it Current Position 2018 - to date “Associate Professor” at the Dept. of Biotechnology and Life Sciences (DBSV) of the University of Insubria, Varese - ITALY. STUDIES 1975-82: “Laurea Universitaria” (Master Degree) in Biological Sciences - 27 January 1982 - score 110/110 - Uni¬ver¬si¬ty of Naples - Italy; 1987-91: Ph.D. in Cellular and Molecular Biology and Pathology - II School of Medicine - “University Federico II” - Naples - Italy. TEACHING ACTIVITY 2019-26 A) “Advances in Biomedicine”. Master Degree Program in “Biomedical Sciences” at the Dep. of Biotechnology and Lie Sciences, University of Insubria, Varese – ITALY B) “Molecular and Cellular oncology. Master Degree Program in “Biomedical Sciences” at the Dep. of Biotechnology and Lie Sciences, University of Insubria, Varese – ITALY RESEARCH ACTIVITY FUNDING as Research Unit 2023-26 PRIN 2022 Epigenetics and conservation of small populations: microevolution and adaptive divergence in relict bear populations. 67.000€ 2019-23 PRIN 2017 Prostate cancer: disentangling the relationships with tumor microenvironment to better model and target tumor progression. 125.000€ 2018-21 Ricerca Finalizzata 2009-1504427 ELF induced maturation and differentiation of human cardiac stem cells and their implantation in nude mice: a preclinical study for treating heart attacks. 195.000 € 2013-15 Italian Association for Cancer Research (AIRC) - Italia. Carcinogen–induced Epigenetic Switching in Human Retroelements: a Mechanistic Study on Benzene Effects. 90.000€ FUNDING as a PI 2013-18 Italian Flagship Program - Epigen Principal Investigator. To investigate the epigenetic basis of the apparent paradox of the co-existence of global hypo and site-specific hyper-methylation of DNA during cancer progression. 600.000 € 2010-13 Italian Association for Cancer Research (AIRC) - Italia. Role of UHRF1/2, essential for DNA methylation, in epigenetic gene silencing of tumour-suppressors. 250.000 € 2009-10 Programmi di ricerca scientifica di rilevante interesse nazionale (PRIN) – Italia (Scientific programs of national interest). La cromatina come substrato d'interrelazione nella dinamica tra replicazione del DNA ed espressione genica (Chromatin as a substrate in the dynamic interrelation between DNA replication and gene expression). 119.000 € BIBLIOMETRIC INDICES. Scopus (January 2026) Results found: 34 Sum of the Times Cited: 1918 h-index: 23 PUBLICATIONS (Selection) 1. Oderda M, Orlando G, Calleris G, Capella G, Delsedime L, Duregon E, di Celle PF, Pacchioni D, Bonapace IM, Zaibunnisa Z, D'Agate D, Montefusco G, Filippini C, Papotti M, Gontero P. Role of Cell-Cycle Proliferation Test, Triple Hit Phenotype, and TMPRSS2-ERG Expression to Evaluate the Risk of Progression in Prostate Cancer Patients Under Active Surveillance. Prostate. 2025 Sep;85(12):1104-1113. doi: 10.1002/pros.24921 2. Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, La Manna F, Ciani Y, Vannuccini F, Mugoni V, Notarangelo M, Libergoli M, Broso F, Taulli R, Ala U, Savino A, Cortese M, Mirzaaghaei S, Poli V, Bonapace IM, Papotti MG, Molinaro L, Doglioni C, Caffo O, Anesi A, Nagler M, Bertalot G, Carbone FG, Barbareschi M, Basso U, Dassi E, Pizzato M, Romanel A, Demichelis F, Kruithof-de Julio M, Lunardi A. Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. EMBO J. 2024 3. Mar;43(5):780-805. doi: 10.1038/s44318-024-00040-5. Epub 2024 Feb 5. PMID: 38316991; 4. Mancini M, Grasso M, Muccillo L, Babbio F, Precazzini F, Castiglioni I, Zanetti V, Rizzo F, Pistore C, De Marino MG, Zocchi M, Del Vescovo V,